Volume 162 opens with an assessment of the modern available data, as well as the results from the authors' own research, on the neurotropic effects of amino acid L-arginine. The effects of L-arginine and some arginine-containing oligopeptides on pain and pain-induced behavior in rats are examined. Depending on their binding to activate specific receptors, antagonists have selective functions. As such, this compilation details their specificity, mode of interactions and their usefulness and drawbacks for humans. Next, a review on how CD14 interacts with different ligands is discussed, particularly focusing on how CD14 consequently transduces the signaling to induce some relevant diseases. The authors also review some trends in the treatment of anxiety with natural compounds and transition metal-catalyzed couplings for the synthesis of new drugs with anxiolytic properties. Natural products have been widely used in the treatment of anxiety disorders and as a source of bioactive heterocyclic compounds. Methods for improving the perception and attitude of health workers towards generic drugs are proposed, such as putting forward generic drugs as one of the learning topics in college curricula, and conducting scientific discussions and conferences on generic drugs through professional organizations. The penultimate study comprehensively reviews the clinicopathological features of lipoblastomas and emphasizes the importance of accurate diagnosis and the differentiation of lipoblastomas from other histologically similar lipomatous neoplasms. The closing study proposes that the relaxant effects of flavone may be due to the inhibition of enzyme activities and intracellular Ca2+ of the trachealis after increasing these two cyclic nucleotides.
