This text is a comprehensive review of oligonucleotide research, covering molecular biological advances in this field, the current status of antisense drug research and strategies for future research and therapeutic applications. In bringing together the latest research, the book provides an integrated conceptual basis for considering oligonucleotide therapeutics. Topics covered include: nucleic acid structure and function, antisense RNA, medicinal chemistry of oligonuleotides, analogues, pharmacokinetics and toxicology, and activities of current antisense drugs.
