There are some things we are not meant to know. Some people know these things anyway. It's hard to be them. Evil and uncanny things are all around, and in sheer self-defense, most people learn not to see.
Fortunately a few people can deal with the truth. From San Fransisco to the Amazonian rainforest, an uncanny group of adventurers fight against the Incumbents. In a milieu wher thaumaturgy is a laboratory science, and raw pain can be kept in a flask of liquid nitrogen, this motley band of alchemists, thaumaturgists and totemists have to save the world that doesn't know it's under attack by forces beyond comprehension.