Charlotte Vickers is a retired police psychic living a lonely existence in Chicago. For years she used her special gift to help local detectives solve hopeless missing-person cases, but now feels burned out. When Natalie Fortunato turns up on her doorstep, looking desperately for her boyfriend, Paul Lattamore, Charlotte reluctantly agrees to help. When Charlotte discovers Paul, happily married and living in Colorado, she decides Natalie should not be told of his whereabouts. But Natalie is actually the daughter of a Mafia don against whom Paul is set to testify, so meanwhile he is living in hiding in a witness protection program, in danger of his life. When Charlotte manages to give Natalie the slip, there begins a terrifying chase across country, with Charlotte's psychic powers pitted against old fashioned torture and murder.