He was educated at Ohio Wesleyan University and Boston University. His simple, optimistic, and dynamic sermons brought increasing numbers of parishioners and increasing fame to Peale. For 54 years Peale's weekly radio program, "The Art of Living," was broadcast on NBC. His sermons were mailed to 750,000 people a month. His life was subject of a 1964 movie entitled One Man's Way.
In 1945, Peale and his wife started Guideposts magazine; its circulation now tops 4.5 million, the largest of any religious magazine. Peale also published several best-selling books, including The Art of Living (1937), Confident Living (1948), The Power of Positive Thinking (1952), and This Incredible Century (1991). His most popular book, The Power of Positive Thinking, has sold more than 20 million copies in 41 languages.