Zack Clarke, his sister Zoe, and pals Rice, Madison, and Ozzie, are off to New York City! It's been six months since the Zombie Chasers saved the country from a mutant virus that transformed the population into brain-craving fiends, and things are finally getting back to normal. Well, normal for everyone else - The Zombie Chasers are heroes and they're going to be on national TV!
Zack is worried enough about his small screen debut, but when the trip goes from sublime to slime after the zombie virus mysteriously reappears, Zack realizes he's got bigger problems. The antidote they created has worn off and the Zombie Chasers are running out of options.
Can they escape the Big Apple with a new cure in hand or is Z day here to stay?